I'm taking the policy of system Python packages installed from distro packages (not pip), but otherwise use virtualenv. Mostly works.
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The most common selling point I hear for Nix is having a list of all the packages you need.
On a traditional Linux distro, I just install things and forget about them. A curated, commented list would certainly be handy when I have a new system.
I've been really enjoying paru as a pacman substitute on Arch Linux: https://github.com/Morganamilo/paru
It allows you to update both normal and AUR packages in one go, which is super convenient. It also shows you PKGBUILD files, so there's still a human audit step for AUR.
I'm never sure what to name my remotes in git. I tend to use 'mine' so I can add other forks later, but sometimes I use 'gh' or the traditional 'origin'.
What do others use?