Strategies for ramping up, working effectively and having fun when you're not using a mainstream programming language: https://morepablo.com/2022/09/so-you-re-using-a-weird-language.html
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Related Posts
DeepMind building an effective StarCraft AI, and why it's a hard game for a computer to play: https://deepmind.com/blog/alphastar-mastering-real-time-strategy-game-starcraft-ii/
(When you build an AI using a ton of self-play, it's pretty likely that you end up finding some novel strategies too!)
If the expression is true, the hardest problem in Computer Science would be naming cache invalidation strategies.