I've found a use for Emacs registers in my workflow! Rather than repeatedly hitting C-y, save important text to a register for easy pasting.
miniblog.
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A really fun (10 minute) talk on developing an LLVM backend for 6502, a chip with only three registers and a teeny tiny stack: https://www.youtube.com/watch?v=2lW3WHPtmKo
x86 Register Encoding https://eklitzke.org/x86-register-encoding (fascinating article on how compilers choose which registers to use — save bytes!)
It's easy to forget how register constrained the x86 architecture is. Even a gameboy had more general purpose registers!