Met a guy a the Emacs meetup who was using Emacs with a Dvorak layout! Impressive! (It did mean no-one else could type, though...)
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Ten years of Dvorak, touch typing, and what to use on smartphones: https://www.theverge.com/2019/2/17/18223384/dvorak-qwerty-keyboard-layout-10-years-speed-ergonomics